Increasing SK2 channel activity impairs associative learning
نویسندگان
چکیده
منابع مشابه
Increasing SK2 channel activity impairs associative learning.
Enhanced intrinsic neuronal excitability of hippocampal pyramidal neurons via reductions in the postburst afterhyperpolarization (AHP) has been hypothesized to be a biomarker of successful learning. This is supported by considerable evidence that pharmacologic enhancement of neuronal excitability facilitates learning. However, it has yet to be demonstrated that pharmacologic reduction of neuron...
متن کاملTitle : Increasing SK 2 Channel Activity Impairs
29 Enhanced intrinsic neuronal excitability of hippocampal pyramidal neurons via 30 reductions in the postburst afterhyperpolarization (AHP) has been hypothesized to be a 31 biomarker of successful learning. This is supported by considerable evidence that 32 pharmacological enhancement of neuronal excitability facilitates learning. However, it 33 has yet to be demonstrated that pharmacological ...
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Apamin-sensitive, small-conductance, Ca2+-activated K+ channels (SK channels) modulate neuronal excitability in CA1 neurons. Blocking all SK channel subtypes with apamin facilitates the induction of hippocampal synaptic plasticity and enhances hippocampal learning. In CA1 dendrites, SK channels are activated by Ca2+ through NMDA receptors and restrict glutamate-mediated EPSPs. Studies of SK cha...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2012
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00025.2012